Publikationsliste

Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2): study protocol for an international, prospective, randomised controlled multicentre trial.  
BMJ Open. 2023;13(3):e070240. doi:10.1136/bmjopen-2022-070240. PMID:36972972.

Mortality rates of severe COVID-19-related respiratory failure with and without extracorporeal membrane oxygenation in the Middle Ruhr Region of Germany.  
Sci Rep. 2023;13(1):5143. doi:10.1038/s41598-023-31944-7. PMID:36991018.

Response to comment on human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis.  
Crit Care. 2023;27(1):464. doi:10.1186/s13054-023-04756-4. PMID:38017441.

Immunogenicity of Bivalent Omicron BA.4/5-Adapted Vaccine in Hemodialysis Patients.  
Kidney Int Rep. 2023;8(4):939-941. doi:10.1016/j.ekir.2023.01.020. PMID:36712412.

Significant Fade of Neutralizing Antibodies and Stable Cellular Immunity in 4 Times COVID-19 Vaccinated Noninfected Compared to COVID-19 Convalescent and 3 Times Vaccinated Hemodialysis Patients.  
Kidney Int Rep. 2023;8(3):685-687. doi:10.1016/j.ekir.2023.01.005. PMID:36644711.

Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.  
EMBO J. 2023;42(5):e112351. doi:10.15252/embj.2022112351. PMID:36762436.

Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infection.  
Front Immunol. 2023;14:1227191. doi:10.3389/fimmu.2023.1227191. PMID:37790937.

Fc N-glycosylation of autoreactive Ab antibodies as a blood-based biomarker for Alzheimer's disease.  
Alzheimers Dement. 2023;19(12):5563-5572. doi:10.1002/alz.13124. PMID:37260026.

Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials.
Br J Anaesth. 2022 Jun;128(6):1040-1051. doi:10.1016/j.bja.2022.02.039. Epub 2022 Apr 15. PMID:35431038.

Schenz J, Rump K, Siegler BH, Hemmerling I, Rahmel T, Thon JN, Nowak H, Fischer D, Hafner A, Tichy L, Bomans K, Meggendorfer M, Koos B, von Groote T, Zarbock A, Fiedler MO, Zemva J, Larmann J, Merle U, Adamzik M, Mueller-Tidow C, Haferlach T, Leuschner F, Weigand MA

Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19
Front Immunol. 2022;13:968778.

Rump K, Spellenberg T, von Busch A, Wolf A, Ziehe D, Thon P, Rahmel T, Adamzik M, Koos B, Unterberg M
AQP5-1364A/C Polymorphism Affects AQP5 Promoter Methylation
Int J Mol Sci. 2022;23(19):11813.


Thon P, Rump K, Knorr A, Dyck B, Ziehe D, Unterberg M, Nowak H, Bergmann L, Wolf A, Bazzi M, Orlowski J, Peters M, Zarbock A, Brenner T, Adamzik M, Rahmel T, Koos B
The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis
Cells. 2022;11(19):3020.


Rump K, Adamzik M
Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and Neuroinflammation
Cells 2022;11(19):2954.


Nowak H, Wolf A, Rahmel T, Oprea G, Grause L, Moeller M, Gyarmati K, Mittler C, Zagler A, Lutz K, Loeser J, Saller T, Tryba M, Adamzik M, Hansen E, Zech N
Therapeutic Suggestions During General Anesthesia Reduce Postoperative Nausea and Vomiting in High-Risk Patients - A Post hoc Analysis of a Randomized Controlled Trial
Front Psychol. 2022 Jul 15;13:898326.


Marko B, Heurich P, Thon P, Zimmer F, Bergmann L, Nowak H, Rump K, Koos B, Adamzik M, Unterberg M, Rahmel T
The Pro-Inflammatory Deletion Allele of the NF-κB1 Polymorphism Is Characterized by a Depletion of Subunit p50 in Sepsis
Int J Mol Sci. 2022 Jul 8;23(14):7559.


Rump K, Holtkamp C, Bergmann L, Nowak H, Unterberg M, Orlowski J, Thon P, Bazzi Z, Bazzi M, Adamzik M, Koos B, Rahmel T
Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?
PLoS One. 2022 Jul 8;17(7):e0271119.


Rahmel T, Kraft F, Haberl H, Achtzehn U, Brandenburger T, Neb H, Jarczak D, Dietrich M, Magunia H, Zimmer F, Basten J, Landgraf C, Koch T, Zacharowski K, Weigand MA, Rosenberger P, Ullrich R, Meybohm P, Nierhaus A, Kindgen-Milles D, Timmesfeld N, Adamzik M
Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study
Crit Care. 2022 Jul 7;26(1):204.


Bachler M, Asmis LM, Koscielny J, Lang T, Nowak H, Paulus P, Schewe JC, von Heymann C, Fries D
Thromboprophylaxis with argatroban in critically ill patients with sepsis: a review
Blood Coagul Fibrinolysis. 2022 Jul 1;33(5):239-256.


Csizmarik A, Keresztes D, Nagy N, Bracht T, Sitek B, Witzke K, Puhr M, Tornyi I, Lázár J, Takács L, Kramer G, Sevcenco S, Maj-Hes A, Jurányi Z, Hadaschik B, Nyirády P, Szarvas T
Proteome profiling of enzalutamide-resistant cell lines and serum analysis identified ALCAM as marker of resistance in castration-resistant prostate cancer
Int J Cancer. 2022 Jun 11. Epub ahead of print.


Meersch M, Weiss R, Küllmar M, Bergmann L, Thompson A, Griep L, Kusmierz D, Buchholz A, Wolf A, Nowak H, Rahmel T, Adamzik M, Haaker JG, Goettker C, Gruendel M, Hemping-Bovenkerk A, Goebel U, Braumann J, Wisudanto I, Wenk M, Flores-Bergmann D, Böhmer A, Cleophas S, Hohn A, Houben A, Ellerkmann RK, Larmann J, Sander J, Weigand MA, Eick N, Ziemann S, Bormann E, Gerß J, Sessler DI, Wempe C, Massoth C, Zarbock A
Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial
JAMA. 2022 Jun 28;327(24):2403-2412.


Varatnitskaya M, Fasel J, Müller A, Lupilov N, Shi Y, Fuchs K, Krewing M, Jung C, Jacob T, Sitek B, Bandow JE, Carroll KS, Hofmann E, Leichert LI
An increase in surface hydrophobicity mediates chaperone activity in N-chlorinated
RidA Redox Biol. 2022 Jul;53:102332.


Schuhenn J, Meister TL, Todt D, Bracht T, Schork K, Billaud JN, Elsner C, Heinen N, Karakoese Z, Haid S, Kumar S, Brunotte L, Eisenacher M, Di Y, Lew J, Falzarano D, Chen J, Yuan Z, Pietschmann T, Wiegmann B, Uebner H, Taube C, Le-Trilling VTK, Trilling M, Krawczyk A, Ludwig S, Sitek B, Steinmann E, Dittmer U, Lavender KJ, Sutter K, Pfaender S
Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2111600119.


Unterberg M, Rahmel T, Rump K, Wolf A, Haberl H, von Busch A, Bergmann L, Bracht T, Zarbock A, Ehrentraut SF, Putensen C, Wappler F, Köhler T, Ellger B, Babel N, Frey U, Eisenacher M, Kleefisch D, Marcus K, Sitek B, Adamzik M, Koos B, Nowak H; SepsisDataNet.NRW research group
The impact of the COVID-19 pandemic on non-COVID induced sepsis survival
BMC Anesthesiol. 2022;22(1):12.


POSE-Study group (u.a. Bergmann L, Nowak H, Unterberg M, Rump K, Oprea G)
Peri-interventional outcome study in the elderly in Europe: A 30-day prospective cohort study
Eur J Anaesthesiol. 2022 Mar 1;39(3):198-209.​


Kowark A, Berger M, Rossaint R, Schmid M, Coburn M; and the POSE-Study group (u.a. Bergmann L, Nowak H, Unterberg M, Rump K, Oprea G)
Association between benzodiazepine premedication and 30-day mortality rate: A propensity-score weighted analysis of the Peri-interventional Outcome Study in the Elderly (POSE)
Eur J Anaesthesiol. 2022 Mar 1;39(3):210-218.​


Keresztes D, Csizmarik A, Nagy N, Módos O, Fazekas T, Bracht T, Sitek B, Witzke K, Puhr M, Sevcenco S, Kramer G, Shariat S, Küronya Z, Takács L, Tornyi I, Lázár J, Hadaschik B, Lászik A, Szűcs M, Nyirády P, Szarvas T
Comparative proteome analysis identified CD44 as a possible serum marker for docetaxel resistance in castration-resistant prostate cancer
J Cell Mol Med.2022 Feb;26(4):1332-1337.​


2021

Funke L, Bracht T, Oeck S, Schork K, Stepath M, Dreesmann S, Eisenacher M, Sitek B, Schramm A
NTRK1/TrkA Signaling in Neuroblastoma Cells Induces Nuclear Reorganization and Intra-Nuclear Aggregation of Lamin A/C
Cancers 2021;13(21):5293.


Unterberg M, Rahmel T, Kissinger T, Petermichl C, Bosmanns M, Niebius M, Schulze C, Jochum HP, Parohl N, Adamzik M, Nowak H
Legionella contamination of a cold-water supplying system in a German university hospital – assessment of the superheat and flush method for disinfection
J Prev Med Hyg. 2021;62:E751-E758.


Magunia H, Lederer S, Verbuecheln R, Gilot BJ, Koeppen M, Haeberle HA, Mirakaj V, Hofmann P, Marx G, Bickenbach J, Nohe B, Lay M, Spies C, Edel A, Schiefenhövel F, Rahmel T, Putensen C, Sellmann T, Koch T, Brandenburger T, Kindgen-Milles D, Brenner T, Berger M, Zacharowski K, Adam E, Posch M, Moerer O, Scheer CS, Sedding D, Weigand MA, Fichtner F, Nau C, Prätsch F, Wiesmann T, Koch C, Schneider G, Lahmer T, Straub A, Meiser A, Weiss M, Jungwirth B, Wappler F, Meybohm P, Herrmann J, Malek N, Kohlbacher O, Biergans S, Rosenberger P
Machine learning identifies ICU outcome predictors in a multicenter COVID-19 cohort
Crit Care. 2021;25(1):295.


Hirschberger S, Strauß G, Effinger D, Marstaller X, Ferstl A, Müller MB, Wu T, Hübner M, Rahmel T, Mascolo H, Exner N, Heß J, Kreth FW, Unger K, Kreth S
Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming
EMBO Mol Med. 2021:e14323.


Wernly B, Beil M, Bruno RR, Binnebössel S, Kelm M, Sigal S, van Heerden PV, Boumendil A, Artigas A, Cecconi M, Marsh B, Moreno R, Oeyen S, Bollen Pinto B, Szczeklik W, Leaver S, Walther SM, Schefold JC, Joannidis M, Fjølner J, Zafeiridis T, de Lange D, Guidet B, Flaatten H, Jung C; VIP2 study group (u.a. Rahmel T)
Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units
BMJ Open. 2021;11(6):e046909.


Haas LEM, Boumendil A, Flaatten H, Guidet B, Ibarz M, Jung C, Moreno R, Morandi A, Andersen FH, Zafeiridis T, Walther S, Oeyen S, Leaver S, Watson X, Boulanger C, Szczeklik W, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjølner J, Artigas A, de Lange DW; VIP2 study group (u.a. Rahmel T)
Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs
Age Ageing. 2021:afab036.


Lill JK, Thiebes S, Pohl JM, Bottek J, Subramaniam N, Christ R, Soun C, Gueler F, Zwanziger D, Hoffmann F, von Eggeling F, Bracht T, Sitek B, Hickey MJ, Hofnagel O, Engel DR
Tissue-resident macrophages mediate neutrophil recruitment and kidney injury in shiga toxin-induced hemolytic uremic syndrome
Kidney Int. 2021:S0085-2538(21)00453-1.


Witzke KE, Großerueschkamp F, Gerwert K, Sitek B
Application of Label-Free Proteomics for Quantitative Analysis of Urothelial Carcinoma and Cystitis Tissue
Methods Mol Biol. 2021;2228:283-292.


May C, Brosseron F, Chartowski P, Fuchs K, Meyer HE, Sitek B, Marcus K
Differential Proteome Analysis Using 2D-DIGE
Methods Mol Biol. 2021;2228:77-84.


May C, Brosseron F, Pfeiffer K, Fuchs K, Meyer HE, Sitek B, Marcus K
Proteome Analysis with Classical 2D-PAGE
Methods Mol Biol. 2021;2228:53-62.


Stepath M, Bracht T
Application of SILAC Labeling in Phosphoproteomics Analysis.
Methods Mol Biol. 2021;2228:167-183.


Barkovits K, Chen W, Kohl M, Bracht T
Targeted Protein Quantification Using Parallel Reaction Monitoring (PRM)
Methods Mol Biol. 2021;2228:145-157


Subramaniam N, Bottek J, Thiebes S, Zec K, Kudla M, Soun C, de Dios Panal E, Lill JK, Pfennig A, Herrmann R, Bruderek K, Rahmann S, Brandau S, Johansson P, Reinhardt HC, Dürig J, Seiffert M, Bracht T, Sitek B, Engel DR
Proteomic and bioinformatic profiling of neutrophils in CLL reveals functional defects that predispose to bacterial infections
Blood Adv. 2021;5(5):1259-1272.


Massoth C, Saadat-Gilani K, Meersch M; HandiCAP Investigators (u.a. Lars Bergmann, Michael Adamzik, Astrid Thompson, Leonore Griep, Desiree Kusmierz, Hartmuth Nowak)
Impact of handover of anesthesia care on adverse postoperative outcomes - The HandiCAP trial
Anaesthesist. 2021;70(4):320-323. (Artikel in Deutsch)


Funke L, Gnipp S, Ahrens M, Eisenacher M, Peters M, Sitek B, Bracht T
Quantitative analysis of proteome dynamics in a mouse model of asthma
Clin Exp Allergy. 2021 Nov;51(11):1471-1481.


Wolf A, Selpien H, Haberl H, Unterberg M
Does a combined intravenous-volatile anesthesia offer advantages compared to an intravenous or volatile anesthesia alone: a systematic review and meta-analysis
BMC Anesthesiol. 2021;21(1):52.


Korbmacher JG, Schulze-Raestrup U, Nowak H, Smektala R
Osteosynthetic treatment of proximal femoral fractures: the timing of treatment is delayed in cases of pre-existing anticoagulation: Results of the data of external inpatient quality assurance from North Rhine-Westphalia with 24,786 cases within the framework of using secondary data
Unfallchirurg. 2021 Aug;124(8):642-650. (Artikel in Deutsch)


Nowak H, Vornweg S, Rump K, Rahmel T, Unterberg M, Koos B, Schenker P, Viebahn R, Adamzik M, Bergmann L
The NFKB1 Promoter Polymorphism (-94ins/delATTG) Is Associated with Susceptibility to Cytomegalovirus Infection after Kidney Transplantation and Should Have Implications on CMV Prophylaxis Regimens
Cells 2021;10(2):380.


2020

Nowak H, Zech N, Asmussen S, Rahmel T, Tryba M, Oprea G, Grause L, Schork K, Moeller M, Loeser J, Gyarmati K, Mittler C, Saller T, Zagler A, Lutz K, Adamzik M, Hansen E
Effect of therapeutic suggestions during general anaesthesia on postoperative pain and opioid use: multicentre randomised controlled trial
BMJ 2020;371:m4284.


Rahmel T, Marko B, Nowak H, Bergmann L, Thon P, Rump K, Kreimendahl S, Rassow J, Peters J, Singer M, Adamzik M, Koos B
Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression
Sci Rep. 2020;10(1):21029.


Koos B, Moderegger EL, Rump K, Nowak H, Willemsen K, Holtkamp C, Thon P, Adamzik M, Rahmel T
LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response
Cells. 2020;9(10):2282.


Bruno RR, Wernly B, Beil M, Muessig JM, Rahmel T, Graf T, Meybohm P, Schaller SJ, Allgäuer S, Franz M, Westphal JG, Barth E, Ebelt H, Fuest K, Horacek M, Schuster M, Dubler S, Schering S, Wolff G, Steiner S, Rabe C, Dieck T, Lauten A, Sacher AL, Brenner T, Bloos F, Jánosi RA, Simon P, Utzolino S, Kelm M, De Lange DW, Guidet B, Flaatten H, Jung C
Therapy limitation in octogenarians in German intensive care units is associated with a longer length of stay and increased 30 days mortality: A prospective multicenter study
J Crit Care. 2020;60:58-63.


Rahmel T, Hübner M, Koos B, Wolf A, Willemsen KM, Strauß G, Effinger D, Adamzik M, Kreth S
Impact of carbohydrate-reduced nutrition in septic patients on ICU: study protocol for a prospective randomised controlled trial
BMJ Open. 2020;10(7):e038532.


Rump K, Rahmel T, Rustige AM, Unterberg M, Nowak H, Koos B, Schenker P, Viebahn R, Adamzik M, Bergmann L
The Aquaporin3 Promoter Polymorphism -1431 A/G is Associated with Acute Graft Rejection and Cytomegalovirus Infection in Kidney Recipients Due to Altered Immune Cell Migration
Cells. 2020;9(6):E1421.


Apfelbacher C, Brandstetter S, Blecha S, Dodoo-Schittko F, Brandl M, Karagiannidis C, Quintel M, Kluge S, Putensen C, Bercker S, Ellger B, Kirschning T, Arndt C, Meybohm P, Weber-Carstens S; DACAPO study group (u.a. Adamzik M, Karlik J, Martini S, Robitzky L), Bein T
uence of quality of intensive care on quality of life/return to work in survivors of the acute respiratory distress syndrome: prospective observational patient cohort study (DACAPO).
BMC Public Health. 2020 Jun 5;20(1):861.


Blecha S, Brandl M, Zeman F, Dodoo-Schittko F, Brandstetter S, Karagiannidis C, Bein T, Apfelbacher C; DACAPO Study Group (u.a. Adamzik M, Karlik J, Martini S, Robitzky L)
Tracheostomy in patients with acute respiratory distress syndrome is not related to quality of life, symptoms of psychiatric disorders or return-to-work: the prospective DACAPO cohort study
Ann Intensive Care. 2020 May 6;10(1):52.


Selpien H, Unterberg M
Perioperative Arzneimittelinteraktionen – was der Anästhesist wissen sollte
Anasthesiol Intensivmed Notfallmed Schmerzther. 2020;55(5):289-299.


Bergmann L, Nowak H, Siffert W, Peters J, Adamzik M, Koos B, Rahmel T
Major Adverse Kidney Events Are Associated with the Aquaporin 5 -1364A/C Promoter Polymorphism in Sepsis: A Prospective Validation Study
Cells. 2020;9(4):940.


Iqbal K, Broeker A, Nowak H, Rahmel T, Nussbaumer-Proell A, Oesterreicher Z, Zeitlinger M, Wicha SG
A pharmacometric approach to define target site-specific breakpoints for bacterial killing and resistance suppression integrating microdialysis, time-kill curves and heteroresistance data: A case study with moxifloxacin
Clin Microbiol Infect 2020;S1198-743X(20)30093-8.


Rahmel T, Schmitz S, Nowak H, Schepanek K, Bergmann L, Halberstadt P, Hörter S, Peters J, Adamzik M
Long-term mortality and outcome in hospital survivors of septic shock, sepsis, and severe infections: The importance of aftercare
PLoS One. 2020;15(2):e0228952.


Guidet B, de Lange DW, Boumendil A, Leaver S, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F, Zafeiridis T, Jung C, Moreno R, Walther S, Oeyen S, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjølner J, Flaatten H; VIP2 study group (u.a. Rahmel T)
The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study
Intensive Care Med. 2020;46(1):57-69.


2019

Rahmel T, Nowak H, Rump K, Koos B, Schenker P, Viebahn R, Adamzik M, Bergmann L
The Aquaporin 5 -1364A/C Promoter Polymorphism Is Associated With Cytomegalovirus Infection Risk in Kidney Transplant Recipients
Front Immunol. 2019;10:2871.


Rump K, Unterberg M, Dahlke A, Nowak H, Koos B, Bergmann L, Siffert W, Schäfer ST, Peters J, Adamzik M, Rahmel T
DNA methylation of a NF-κB binding site in the aquaporin 5 promoter impacts on mortality in sepsis
Sci Rep. 2019;9(1):18511.


Nowak H, Weidemann C, Martini S, Oesterreicher ZA, Dorn C, Adamzik M, Kees F, Zeitlinger M, Rahmel T
Repeated determination of moxifloxacin concentrations in interstitial space fluid of muscle and subcutis in septic patients
J Antimicrob Chemother. 2019;74(9):2681-2689.


Brandstetter S, Dodoo-Schittko F, Brandl M, Blecha S, Bein T, Apfelbacher C; DACAPO study group (u.a. Adamzik M, Karlik J, Martini S, Robitzky L)
Ambulatory and stationary healthcare use in survivors of ARDS during the first year after discharge from ICU: findings from the DACAPO cohort
Ann Intensive Care. 2019;9(1):70


Unterberg M, Nowak H
Increased Arterial Blood-Pressure Previous to Elective Surgery - How to Proceed?
Anasthesiol Intensivmed Notfallmed Schmerzther. 2019;54(5):348-354 (Artikel in Deutsch)


Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology, Bluth T, Serpa Neto A, Schultz MJ, Pelosi P, Gama de Abreu M; Investigators (u.a. Bergmann L, Ebner F, Mölders P, Robitzky L, Unterberg M)
Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial
JAMA. 2019;322(18):1829-1830.


Wolf A, Mölders P, Yilmaz U
Stroke Thrombectomy: Anaesthesiologic Aspects
Anasthesiol Intensivmed Notfallmed Schmerzther. 2019 Apr;54(4):283-293 (Artikel in Deutsch)


Holtkamp C, Koos B, Unterberg M, Rahmel T, Bergmann L, Bazzi Z, Bazzi M, Bukhari H, Adamzik M, Rump K
A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes
PLoS One. 2019;14(5):e0217269


Rahmel T, Koniusch A, Schwertner M, Oprea G, Adamzik M, Nowak H
Evaluation of inhaled salbutamol effectiveness under supportive use of electrical impedance tomography in ventilated ICU patients: study protocol for a randomised controlled clinical trial
BMJ Open. 2019;9(3):e026038


Rahmel T, Rump K, Peters J, Adamzik M
Aquaporin 5 -1364A/C Promoter Polymorphism Is Associated with Pulmonary Inflammation and Survival in Acute Respiratory Distress Syndrome
Anesthesiology. 2019;130(3):404-413


Kalvelage C, Zacharowski K, Bauhofer A, Gockel U, Adamzik M, Nierhaus A, Kujath P, Eckmann C, Pletz MW, Bracht H, Simon TP, Winkler M, Kindgen-Milles D, Albertsmeier M, Weigand M, Ellger B, Ragaller M, Ullrich R, Marx G
Personalized medicine with IgGAM compared with standard of care for treatment of peritonitis after infectious source control (the PEPPER trial): study protocol for a randomized controlled trial
Trials. 2019;20(1):156


2018

Fichtner F, Moerer O, Laudi S, Weber-Carstens S, Nothacker M, Kaisers U; Investigators and the Guideline Group on Mechanical Ventilation and Extracorporeal Membrane Oxygenation in Acute Respiratory Insufficiency (u.a. Adamzik M)
Mechanical Ventilation and Extracorporeal Membrane Oxygena tion in Acute Respiratory Insufficiency
Dtsch Arztebl Int. 2018;115(50):840-847


Rahmel T, Nowak H, Rump K, Siffert W, Peters J, Adamzik M
The aquaporin 5 -1364A/C promoter polymorphism impacts on resolution of acute kidney injury in pneumonia evoked ARDS
PLoS One. 2018;13(12):e0208582


Donauer K, Bomberg H, Wagenpfeil S, Volk T, Meissner W, Wolf A
Regional vs. General Anesthesia for Total Knee and Hip Replacement: An Analysis of Postoperative Pain Perception from the International PAIN OUT Registry
Pain Pract. 2018;18(8):1036-1047


Mölders P, Alders BJ
Synopsis Neuroanesthesia: Brain, Anesthetics and Skills
Anasthesiol Intensivmed Notfallmed Schmerzther. 2018;53(9):618-630 (Artikel in Deutsch)


Muessig JM, Nia AM, Masyuk M, Lauten A, Sacher AL, Brenner T, Franz M, Bloos F, Ebelt H, Schaller SJ, Fuest K, Rabe C, Dieck T, Steiner S, Graf T, Jánosi RA, Meybohm P, Simon P, Utzolino S, Rahmel T, Barth E, Schuster M, Kelm M, Jung C
Clinical Frailty Scale (CFS) reliably stratifies octogenarians in German ICUs: a multicentre prospective cohort study
BMC Geriatr. 2018;18(1):162


Nowak H, Unterberg M
Oral Anticoagulants: Management of Elective and Emergency Surgery
Anasthesiol Intensivmed Notfallmed Schmerzther. 2018;53(7):543-550 (Artikel in Deutsch)


Schulte K, Borzikowsky C, Rahmel A, Kolibay F, Polze N, Fränkel P, Mikle S, Alders B, Kunzendorf U, Feldkamp T
Decline in organ donation in Germany - a nationwide secondary analysis of all inpatient cases
Dtsch Arztebl Int 2018;115:463-468


Rahmel T, Rump K, Adamzik M, Peters J, Frey UH
Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome
BMC Anesthesiol. 2018;18(1):75


Bergmann L
Safe Vascular Access - the Guideline of the Association of Anaesthesists of Great Britain and Ireland 2016
Anasthesiol Intensivmed Notfallmed Schmerzther. 2018;53(6):458-465 (Artikel in Deutsch)


Klenke S, Eul S, Peters J, Neumann T, Adamzik M, Frey UH
Circulating miR-192 is a prognostic marker in patients with ischemic cardiomyopathy
Future Cardiol. 2018;14(4):283-289


Rahmel T, Schäfer ST, Frey UH, Adamzik M, Peters J
Increased circulating microRNA-122 is a biomarker for discrimination and risk stratification in patients defined by sepsis-3 criteria
PLoS One 2018;13(5):e0197637


Guidet B, Flaatten H, Boumendil A, Morandi A, Andersen FH, Artigas A, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Zafeiridis T, De Lange DW; VIP1 study group (u.a. Rahmel T)
Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit
Intensive Care Med. 2018;44(7):1027-1038


Dodoo-Schittko F, Brandstetter S, Brandl M, Blecha S, Quintel M, Weber-Carstens S, Kluge S, Kirschning T, Muders T, Bercker S, Ellger B, Arndt C, Meybohm P, Adamzik M, Goldmann A, Karagiannidis C, Bein T, Apfelbacher C; DACAPO Study Group (u.a. Karlik J, Martini S, Robitzky L)
German-wide prospective DACAPO cohort of survivors of the acute
respiratory distress syndrome (ARDS): a cohort profile
BMJ Open 2018;8(4):e019342


Rump K, Adamzik M
Function of aquaporins in sepsis: a systematic review
Cell Biosci 2018;8:10


Blecha S, Dodoo-Schittko F, Brandstetter S, Brandl M, Dittmar M, Graf BM, Karagiannidis C, Apfelbacher C, Bein T; DACAPO Study Group (u.a. Adamzik M, Karlik J, Martini S, Robitzky L)
Quality of inter-hospital transportation in 431 transport survivor patients suffering from acute respiratory distress syndrome referred to specialist centers
Ann Intensive Care 2018;8(1):5


Rahmel T
SSC International Guideline 2016 - Management of Sepsis and Septic Shock
Anasthesiol Intensivmed Notfallmed Schmerzther. 2018;53(2):142-148 (Artikel in Deutsch


2017

Flaatten H, De Lange DW, Morandi A, Andersen FH, Artigas A, Bertolini G, Boumendil A, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Zaferidis, Guidet; VIP1 study group (u.a. Rahmel T)
The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years)
Intensive Care Med. 2017;43(12):1820-1828


Hilder M, Herbstreit F, Adamzik M, Beiderlinden M, Bürschen M, Peters J, Frey UH
Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score)
Crit Care. 2017;21(1):301


Asmussen S, Maybauer DM, Chen JD, Fraser JF, Toon MH, Przkora R, Jennings K, Maybauer MO
Effects of Acupuncture in Anesthesia for Craniotomy: A Meta-Analysis
J Neurosurg Anesthesiol. 2017;29(3):219-227


Kottenberg E, Frey U, Brendt P, Bergmann L, Heine T, Lütkes P, Forsting M, Peters J
Cerebral Events are not Predicted by Near-Infrared Spectroscopy during Anesthesia for Aortic Arch Surgery with Bilateral Antegrade Selective Cerebral Perfusion and Hypothermic Circulatory Arrest
JSM Cardiothorac Surg 2(2):1011.

Rahmel T, Asmussen S, Karlik J, Steinmann J, Adamzik M, Peters J
Moxifloxacin monotherapy versus combination therapy in patients with severe community-acquired pneumonia evoked ARDS
BMC Anesthesiol 2017;17(1):78


Sanfilippo F, Asmussen S, Maybauer DM, Santonocito C, Fraser JF, Erdoes G, Maybauer MO
Bivalirudin for Alternative Anticoagulation in Extracorporeal Membrane Oxygenation: A Systematic Review
J Intensive Care Med. 2017;32(5):312-319


Asmussen S, Przkora R, Maybauer DM, Fraser JF, Sanfilippo F, Jennings K, Adamzik M, Maybauer MO
Meta-Analysis of Electroacupuncture in Cardiac Anesthesia and Intensive Care
J Intensive Care Med. 2017 1:885066617708558


Unterberg M, Nowak H, Gottschalk A
Hypercapnic Raised Intracerebral Pressure - ECMO Therapy Despite Major Intracerebral Haemorrhage
Anasthesiol Intensivmed Notfallmed Schmerzther. 2017;52(5):376-381 (Artikel in Deutsch)


Dötsch A, Eisele L, Rabeling M, Rump K, Walstein K, Bick A, Cox L, Engler A, Bachmann HS, Jöckel KH, Adamzik M, Peters J, Schäfer ST
Hypoxia Inducible Factor-2 Alpha and Prolinhydroxylase 2 Polymorphisms in Patients with Acute Respiratory Distress Syndrome (ARDS)
Int J Mol Sci. 2017 14;18(6)


Bluth T, Teichmann R, Kiss T, Bobek I, Canet J, Cinnella G, De Baerdemaeker L, Gregoretti C, Hedenstierna G, Hemmes SN, Hiesmayr M, Hollmann MW, Jaber S, Laffey JG, Licker MJ, Markstaller K, Matot I, Müller G, Mills GH, Mulier JP, Putensen C, Rossaint R, Schmitt J, Senturk M, Serpa Neto A, Severgnini P, Sprung J, Vidal Melo MF, Wrigge H, Schultz MJ, Pelosi P, Gama de Abreu M; PROBESE investigators (u.a. Bergmann L, Ebner F, Robitzky L, Mölders P, Unterberg M); and the PROtective VEntilation Network (PROVEnet); Clinical Trial Network of the European Society of Anaesthesiology (ESA)
Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial
Trials 2017;18(1):202


Kühnle E, Unterberg M, Köditz R, Roukens R, Tegenthoff M, Schwenkreis P, Kitzrow M, Schmidt-Wilcke T
Ein erstaunlich guter Verlauf bei einer Patientin nach kardiopulmonaler Reanimation trotz Burst-Suppression-Muster und NSE-Werten über 100 μg/l
Neurol Rehabil 2017;23(1):99-102

Dorn C, Nowak H, Weidemann C, Martini S, Zeitlinger M, Adamzik M, Kees F
Decreases protein binding of moxifloxacin in patients with sepsis?
GMS Infect Dis 2017;5:Doc03

2016

Höcker A, Rabeling M, Bick A, Cox L, Kreuzer M, Engler A, Walstein K, Bachmann HS, Jöckel KH, Eisele L, Adamzik M, Peters J, Schäfer ST
Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial
BMC Anesthesiol. 2016 Aug 11;16(1):61


Rump K, Unterberg M, Bergmann L, Bankfalvi A, Menon A, Schäfer S, Scherag A, Bazzi Z, Siffert W, Peters J, Adamzik M
AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study
J Transl Med. 2016 Nov 21;14(1):321


SepNet Critical Care Trials Group. (u.a. Bergmann L, Martini S, Adamzik M)
Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study
Intensive Care Med. 2016 Dec;42(12):1980-1989


Bergmann L, Martini S, Kesselmeier M, Armbruster W, Notheisen T, Adamzik M, Eichholz R
Phrenic nerve block caused by interscalene brachial plexus block: breathing effects of different sites of injection
BMC Anesthesiol. 2016 Jul 29;16(1):45


Unterberg M, Kreuzer MJ, Schäfer ST, Bazzi Z, Adamzik M, Rump K
NFKB1 Promoter DNA from nt+402 to nt+99 Is Hypomethylated in Different Human Immune Cells
PLoS One. 2016 Jun 1;11(6):e0156702


Rump K, Siffert W, Peters J, Adamzik M
The Transcription Factor NMP4 Binds to the AQP5 Promoter and Is a Novel Transcriptional Regulator of the AQP5 Gene
DNA Cell Biol. 2016 Jul;35(7):322-7


Schäfer ST, Franken L, Adamzik M, Schumak B, Scherag A, Engler A, Schönborn N, Walden J, Koch S, Baba HA, Steinmann J, Westendorf AM, Fandrey J, Bieber T, Kurts C, Frede S, Peters J, Limmer A
Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis
Anesthesiology. 2016 Apr;124(4):923-33


2015

van Zaane B, van Klei WA, Buhre WF, Bauer P, Boerma EC, Hoeft A, Metnitz P, Moreno RP, Pearse R, Pelosi P, Sander M, Vallet B, Pettilä V, Vincent JL, Rhodes A; unter Beteiligung von Unterberg M, Piontek A
European Surgical Outcomes Study (EuSOS) group for the Trials groups of the European Society of Intensive Care Medicine and the European Society of Anaesthesiology
Eur J Anaesthesiol. 2015 Jul;32(7):477-85


Rath PM1, Schoch B, Adamzik M, Steinmann E, Buer J, Steinmann J
Reply: PCR assay for pathogen detection in ventriculostomy-related meningitis in neurosurgery patients: unanswered questions?
Infection. 2015 Apr;43(2):251-2


2014

Gottschalk A, Rink B, Smektala R, Piontek A, Ellger B, Gottschalk A
Spinal anesthesia protects against perioperative hyperglycemia in patients undergoing hip arthroplasty
J Clin Anesth. 2014 Sep 5. pii: S0952-8180(14)00107-X


Schäfer ST, Gessner S, Scherag A, Rump K, Frey UH, Siffert W, Westendorf AM, Steinmann J, Peters J, Adamzik M
Hydrocortisone Fails to Abolish NF-κB1 Protein Nuclear Translocation in Deletion Allele Carriers of the NFKB1 Promoter Polymorphism (-94ins/delATTG) and Is Associated with Increased 30-Day Mortality in Septic Shock
PLoS One. 2014 Aug 18;9(8):e104953


Rump K, Brendt P, Frey UH, Schäfer ST, Siffert W, Peters J, Adamzik M
Aquaporin 1 and 5 expression evoked by the β2 adrenoreceptor agonist terbutaline and lipopolysaccharide in mice and in the human monocytic cell line THP-1 is differentially regulated
Shock. 2013 Nov;40(5):430-6


Schneider G, Jordan D, Schwarz G, Bischoff P, Kalkman CJ, Kuppe H, Rundshagen I, Omerovic A, Kreuzer M, Stockmanns G, Kochs EF; European Multicenter EEGAEP Anesthesia Monitoring Study Group and Research Group Knowledge-based Signal Processing
Monitoring depth of anesthesia utilizing a combination of electroencephalographic and standard measures
Anesthesiology. 2014 Apr;120(4):819-28


2013

El Hindy N, Rump K, Lambertz N, Zhu Y, Frey UH, Bankfalvi A, Siffert W, Sure U, Peters J, Adamzik M, Sandalcioglu IE
The functional Aquaporin 1 -783G/C-polymorphism is associated with survival in patients with glioblastoma multiforme
J Surg Oncol. 2013 Dec;108(7):492-8


Adamzik M
"Book of life" : On course for personalized anesthesia?
Anaesthesist. 2013 Nov;62(11):872-3


Adamzik M, Broll J, Steinmann J, Westendorf AM, Rehfeld I, Kreissig C, Peters J
An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality
Intensive Care Med. 2013 Oct;39(10):1743-51


Schäfer ST, Frede S, Winning S, Bick A, Roshangar P, Fandrey J, Peters J, Adamzik M
Hypoxia-inducible factor and target gene expression are decreased in patients with sepsis: prospective observational clinical and cellular studies
Anesthesiology. 2013 Jun;118(6):1426-36


Kahlert P, Al-Rashid F, Plicht B, Hildebrandt H, Patsalis P, Chilali KE, Wendt D, Thielmann M, Bergmann L, Kottenberg E, Schlamann M, Eggebrecht H, Jakob H, Heusch G, Konorza T, Erbel R
Incidence, predictors, origin and prevention of early and late neurological events after transcatheter aortic valve implantation (TAVI): a comprehensive review of current data
J Thromb Thrombolysis. 2013 May;35(4):436-49


Kahlert P, Al-Rashid F, Döttger P, Mori K, Plicht B, Wendt D, Bergmann L, Kottenberg E, Schlamann M, Mummel P, Holle D, Thielmann M, Jakob HG, Heusch G, Erbel R, Eggebrecht H
Response to letters regarding article, “cerebral embolization during transcatheter aortic valve implantation: a transcranial Doppler study”
Circulation. 2013 May 7;127(18):e591-2


Gottschalk A, Seelen S, Tivey S, Gottschalk A, Rich G
What do patients know about anesthesiologists? Results of a comparative survey in an U.S., Australian, and German university hospital
J Clin Anesth. 2013 Mar;25(2):85-91


2012

Pearse RM, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent JL, Hoeft A, Rhodes A; unter Beteiligung von Unterberg M, Piontek A
European Surgical Outcomes Study (EuSOS) group for the Trials groups of the European Society of Intensive Care Medicine and the European Society of Anaesthesiology
Lancet. 2012 Sep 22;380(9847):1059-65