Die Ruhr-Epileptologie versteht sich als universitäres Epilepsiezentrum und trägt im Rahmen klinischer Forschung zur Weiterentwicklung von Diagnose- und Behandlungsverfahren bei. Eine Auswahl aktueller Forschungsvorhaben ist:
Publikationsliste Ruhr-Epileptologie 2010 bis jetzt
Unnwongse K, Rampp S, Wehner T, Kowoll A, Parpaley Y, von Lehe M, Lanfer B, Rusiniak M, Wolters C, Wellmer J. Validating EEG source imaging using intracranial electrical stimulation. Brain Commun. 2023 Feb 7;5(1):fcad023.
Grönheit W, Behrens V, Liakina T, Kellinghaus C, Noachtar S, Popkirov S, Wehner T, Brammen E, Wellmer J. Teaching distinguishing semiological features improves diagnostic accuracy of seizure-like events by emergency physicians. Neurol Res Pract. 2022 Nov 14;4(1):56.
Seidel S, Wehner T, Miller D, Wellmer J, Schlegel U, Grönheit W. Brain tumor related epilepsy: pathophysiological approaches and rational management of antiseizure medication. Neurol Res Pract. 2022 Sep 5;4(1):45.
Michaelis R, Schlömer S, Popkirov S, Krämer G, Lindemann A, Cosentino M, Reuber M, Heinen G, Wellmer J, Grönheit W, Wehner T, Schlegel U, Scott AJ, Gandy M. German translation and validation of the brief Epilepsy Anxiety Survey Instrument (brEASI). Epilepsy Behav. 2022 Sep;134:108857.
Bellartz E, Pertz M, Jungilligens J, Kleffner I, Wellmer J, Schlegel U, Thoma P, Popkirov S. Point-of-Care Testing Using a Neuropsychology Pocketcard Set: A Preliminary Validation Study. Brain Sci. 2022 May 27;12(6):694.
Drexler R, Ben-Haim S, Bien CG, Borger V, Cardinale F, Carpentier A, Cendes F, Chandra S, Clusmann H, Colon A, de Curtis M, Delev D, Didato G, Dührsen L, Farah JO, Guenot M, Ghatan S, Haegelen C, Hamer H, Hauptmann JS, Jeffree RL, Kalbhenn T, Kegele J, Krayenbühl N, Lang J, Mathon B, Naros G, Onken J, Panov F, Raftopoulos C, Ricklefs FL, Rijkers K, Rizzi M, Rössler K, Schijns O, Schneider UC, Spyrantis A, Strzelczyk A, Stodieck S, Tripathi M, Vadera S, Alonso-Vanegas MA, Vaz JGR, Wellmer J, Wehner T, Westphal M, Sauvigny T. Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry. Front Neurol. 2021 Dec 13;12:782666.
Michaelis R, Schlömer S, Lindemann A, Behrens V, Grönheit W, Pertz M, Rammé S, Seidel S, Wehner T, Wellmer J, Schlegel U, Popkirov S. Screening for Psychiatric Comorbidities and Psychotherapeutic Assessment in Inpatient Epilepsy Care: Preliminary Results of an Implementation Study. Front Integr Neurosci. 2021 Oct 12;15:754613.
Wehner T, Weckesser P, Schulz S, Kowoll A, Fischer S, Bosch J, Weinhold L, Fimmers R, Schmid M, Wellmer J. Factors influencing the detection of treatable epileptogenic lesions on MRI. A randomized prospective study. Neurol Res Pract. 2021 Aug 9;3(1):41.
Rammé S, Mues S, Popkirov S, Widman G, Zuberi SM, Wellmer J (2021) Handyvideos als diagnostisches Instrument anfallsartig auftretender Ereignisse. Z.Epileptolol. 34: 284-288
Mues S, Grönheit W, Wehner T, Wellmer J (2021) Tele-Epileptologie Ruhr: Zwischenevaluation eines telemedizinischen Modellprojektes. Z.Epileptolol. 34: 311-317
Grönheit W, Behrens V, Liakina T, Kellinghaus C, Noachtar S, Popkirov S, Wehner T, Brammen E, Wellmer J (2022) Teaching distinguishing semiological features improves diagnostic accuracy of seizure-like events bey emergency physicians. Neurology Research and Practice: Under revision
Mues S, Hamer HM, von Podewils F, Sotoodeh A, Rosenow F, Wellmer J, Zöllner JP. Telemedizin in der Epilepsieversorgung: Arzt-zu-Arzt-Anwendungen. Teil I: State-of-the-Art, Herausforderungen, Perspektiven Z. Epileptol. 34, 294–298 (2021).
Mues S, Hamer HM, von Podewils F, Sotoodeh A, Rosenow F, Wellmer J, Zöllner JP.Telemedizin in der Epilepsieversorgung: Arzt-zu-Arzt-Anwendungen. Teil II: Aktuelle Projekte in Deutschland Z. Epileptol. 34, 299–305 (2021).
Ismail FS, Spatola M, Woermann FG, Popkirov S, Jungilligens J, Bien CG, Wellmer J, Schlegel U. Diagnostic challenges in patients with temporal lobe seizures and features of autoimmune limbic encephalitis. Eur J Neurol. 2022 May;29(5):1303-1310.
David B, Kröll-Seger J, Schuch F, Wagner J, Wellmer J, Woermann F, Oehl B, Van Paesschen W, Breyer T, Becker A, Vatter H, Hattingen E, Urbach H, Weber B, Surges R, Elger CE, Huppertz HJ, Rüber T. External validation of automated focal cortical dysplasia detection using morphometric analysis. Epilepsia. 2021 Apr;62(4):1005-1021.
Jungilligens J, Wellmer J, Kowoll A, Schlegel U, Axmacher N, Popkirov S. Microstructural integrity of affective neurocircuitry in patients with dissociative seizures is associated with emotional task performance, illness severity and trauma history. Seizure. 2021 Jan;84:91-98.
Saif-Ur-Rehman M, Ali O, Dyck S, Lienkämper R, Metzler M, Parpaley Y, Wellmer J, Liu C, Lee B, Kellis S, Andersen R, Iossifidis I, Glasmachers T, Klaes C. SpikeDeep-classifier: a deep-learning based fully automatic offline spike sorting algorithm. J Neural Eng. 2021 Feb 5;18(1).
Popkirov S, Grönheit W, Jungilligens J, Wehner T, Schlegel U, Wellmer J. Suggestive seizure induction for inpatients with suspected psychogenic nonepileptic seizures. Epilepsia. 2020 Sep;61(9):1931-1938.
Jungilligens J, Wellmer J, Schlegel U, Kessler H, Axmacher N, Popkirov S. Impaired emotional and behavioural awareness and control in patients with dissociative seizures. Psychol Med. 2020 Dec;50(16):2731-2739.
Ramm M, Möddel G, Sundermann B, Last A, Langenbruch L, Jungilligens J, Wellmer J, Young P, Axmacher N. Impaired processing of response conflicts in mesial temporal lobe epilepsy. J Neuropsychol. 2020 Jun;14(2):283-300.
Saif-Ur-Rehman M, Lienkämper R, Parpaley Y, Wellmer J, Liu C, Lee B, Kellis S, Andersen R, Iossifidis I, Glasmachers T, Klaes C. SpikeDeeptector: a deep-learning based method for detection of neural spiking activity. J Neural Eng. 2019 Jul 23;16(5):056003.
Grönheit W, Popkirov S, Wehner T, Schlegel U, Wellmer J. Practical Management of Epileptic Seizures and Status Epilepticus in Adult Palliative Care Patients. Front Neurol. 2018 Aug 2;9:595.
Kasper BS, Rössler K, Hamer HM, Dörfler A, Blümcke I, Coras R, Roesch J, Mennecke A, Wellmer J, Sommer B, Lorber B, Lang JD, Graf W, Stefan H, Schwab S, Buchfelder M, Rampp S. Coregistrating magnetic source and magnetic resonance imaging for epilepsy surgery in focal cortical dysplasia. Neuroimage Clin. 2018 May 1;19:487-496.
Popkirov S, Jungilligens J, Schlegel U, Wellmer J. Research on dissociative seizures: A bibliometric analysis and visualization of the scientific landscape. Epilepsy Behav. 2018 Jun;83:162-167.
Popkirov S, Ismail FS, Grönheit W, Kapauer M, Wellmer J, Bien CG. Progressive hippocampal sclerosis after viral encephalitis: Potential role of NMDA receptor antibodies. Seizure. 2017;51:6-8.
Wellmer J, Machado M, von Lehe M, Voges J, Parpaley Y. Läsionsorientierte Radiofrequenz-Thermokoagulation (L-RFTC) fokaler kortikaler Dysplasien. Z Epileptol 2017;30:105–112.
Voges J, Wellmer J, Büntjen L, Schmitt FC. Radiofrequenz-Thermoablation – die neurochirurgische Sicht. Z Epileptol 2017;30:98–104.
Popkirov S, Jungilligens J, Grönheit W, Wellmer J. Diagnosing psychogenic nonepileptic seizures: Video-EEG monitoring, suggestive seizure induction and diagnostic certainty. Epilepsy Behav. 2017;73:54-58.
Popkirov S, Ayzenberg I, Hahn S, Bauer J, Denno Y, Rieckhoff N, Radzimski C, Hans VH, Berg S, Roghmann F, Noldus J, Bien CG, Skodda S, Wellmer J, Stöcker W, Krogias C, Gold R, Schlegel U, Probst C, Komorowski L, Miske R, Kleiter I. Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis. Acta Neuropathol Commun. 2017;5:40.
Aydin Ü, Rampp S, Wollbrink A, Kugel H, Cho J-, Knösche TR, Grova C, Wellmer J, Wolters CH. Zoomed MRI Guided by Combined EEG/MEG Source Analysis: A Multimodal Approach for Optimizing Presurgical Epilepsy Work-up and its Application in a Multi-focal Epilepsy Patient Case Study. Brain Topogr. 2017;30:417-433.
Popkirov S, Grönheit W, Wellmer J. Paroxysmal belching: Epileptic or nonepileptic? Epilepsy Behav Case Rep. 2016;5:11-2.
Wellmer J, Voges J, Parpaley Y. Lesion guided radiofrequency thermocoagulation (L-RFTC) for hypothalamic hamartomas, nodular heterotopias and cortical dysplasias: review and perspective. Seizure 2016;41:206-10.
Wellmer J, Parpaley Y, Rampp S, Popkirov S, Kugel H, Aydin Ü, Wolters CH, von Lehe M, Voges J. Lesion guided stereotactic radiofrequency thermocoagulation for palliative, in selected cases curative epilepsy surgery. Epilepsy Res. 2016;121:39-46
Ismail FS, Popkirov S, Wellmer J, Grönheit W. Faciobrachio-crural dystonic seizures in LGI1 limbic encephalitis: A treatable cause of falls. Neurol Neuroimmunol Neuroinflamm October 2015 vol. 2 no. 5 e146.
Popkirov S, Grönheit W, Wellmer J. A systematic review of suggestive seizure induction for the diagnosis of psychogenic nonepileptic seizures. Seizure. 2015;31:124-32.
Popkirov S, Grönheit W, Wellmer J. Hyperventilation and photic stimulation are useful additions to a placebo-based suggestive seizure induction protocol in patients with psychogenic nonepileptic seizures. Epilepsy Behav. 2015;46:88-90.
Aydin Ü, Vorwerk J, Dümpelmann M, Küpper P, Kugel H, Heers M, Wellmer J, Kellinghaus C, Haueisen J, Rampp S, Stefan H, Wolters CH. Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis. PLoS One. 2015;11;10(3).
Heers M, Hirschmann J, Jacobs J, Dümpelmann M, Butz M, von Lehe M, Elger CE, Schnitzler A, Wellmer J. Frequency domain beamforming of magnetoencephalographic beta band activity in epilepsy patients with focal cortical dysplasia. Epilepsy Res. 2014;108:1195-203.
Popkirov S, Grönheit W, Schlegel U, Wellmer J. Recurrent loss of consciousness despite DDD pacing: psychogenic pseudosyncope in a 19-year-old man. Clin Res Cardiol. 2014;103:755-7.
Aydin Ü, Vorwerk J, Küpper P, Heers M, Kugel H, Galka A, Hamid L, Wellmer J, Kellinghaus C, Rampp S, Wolters CH. Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model. PLoS One. 201426;9(3):e93154.
Wellmer J, Kopitzki K, Voges J. Lesion focused stereotactic thermo-coagulation of focal cortical dysplasia IIB: a new approach to epilepsy surgery? Seizure. 2014;23:475-8.
Wellmer J, Quesada CM, Rothe L, Elger CE, Bien CG, Urbach H. Proposal for a magnetic resonance imaging protocol for the detection of epileptogenic lesions at early outpatient stages. Epilepsia. 2013;54:1977-87.
Sammler D, Koelsch S, Ball T, Brandt A, Grigutsch M, Huppertz HJ, Knösche TR, Wellmer J, Widman G, Elger CE, Friederici AD, Schulze-Bonhage A. Co-localizing linguistic and musical syntax with intracranial EEG. Neuroimage. 2013;64:134-46.
Wellmer J, von der Groeben F, Klarmann U, Weber C, Elger CE, Urbach H, Clusmann H, von Lehe M. Risks and benefits of invasive epilepsy surgery workup with implanted subdural and depth electrodes. Epilepsia. 2012;53:1322-32
Heers M, Rampp S, Stefan H, Urbach H, Elger CE, von Lehe M, Wellmer J. MEG-based identification of the epileptogenic zone in occult peri-insular epilepsy. Seizure 2012;21:128-33.
von Lehe M, Wagner J, Wellmer J, Clusmann H, Kral T. Epilepsy surgery of the cingulate gyrus and the fronto-mesial cortex. Neurosurgery. 2012;70:900-10.
Wagner J, Urbach H, Niehusmann P, von Lehe M, Elger CE, Wellmer J. Focal cortical dysplasia type IIb: completeness of cortical, not subcortical, resection is necessary for seizure freedom. Epilepsia. 2011;52:1418-24.
Niehusmann P, Surges R, von Wrede RD, Elger CE, Wellmer J, Reimann J, Urbach H, Vielhaber S, Bien CG, Kunz WS. Mitochondrial dysfunction due to Leber's hereditary optic neuropathy as a cause of visual loss during assessment for epilepsy surgery. Epilepsy Behav. 2011;20:38-43.
Wellmer J, Parpaley Y, von Lehe M, Huppertz HJ. Integrating MRI post-processing results into neuronavigation for electrode implantation and resection of subtle focal cortical dysplasia in previously cryptogenic epilepsy. Neurosurgery 2010; 66:187-94.
Horstmann MT, Bialonski S, Noennig H, Mai H, Prusseit J, Wellmer J, Hinrichs H, Lehnertz K. State dependent properties of epileptic brain networks: Comparative graph-theoretical analyses of simultaneous recorded EEG and MEG. Clin Neurophysiol. 2010;121:172-85